Don't be fooled by Cam Newton's record-setting performance in Week 1. The rookie gunslinger did it against perhaps the softest defense in the league.

QB Ryan Fitzpatrick, Bills: Let your opponent slobber all over Newton. Grab the guy with more experience, who was a borderline fantasy starter for much of 2010. Fitzpatrick will be a more reliable QB2, and he has a softer schedule.

RB Ben Tate, Texans: All he needed was an opportunity, and he got it Sunday. Though Arian Foster should be back this weekend, Tate will be the preferred handcuff, especially if Derrick Ward’s ankle injury lingers.

RB Cadillac Williams, Rams: When Steven Jackson left early with a quadriceps injury, Cadillac came in and proved he still has plenty left in the tank.

WR Randall Cobb, Packers: We all know rookie receivers rarely can be trusted. But when his quarterback is Aaron Rodgers and he has a two-touchdown debut, conventional wisdom goes out the window.

TE Scott Chandler, Bills: Though the journeyman has amassed a grand total of one eight-yard reception in his first four seasons, Fitzgerald needs a complementary receiver to Johnson now that Lee Evans is gone.

K John Kasay, Saints: You’ll need to go kicker shopping if you just lost Nate Kaeding for the season. Kasay is available in about half of all

QB Cam Newton, Panthers: After his record-setting debut, he'll be the hottest free-agent commodity in Fantasyland. But before you burn your waiver priority, note that he just played the softest defense he’ll see all season.

QB Donovan McNabb, Vikings: Is he still sitting on your bench? What are you waiting for? Dump him now before you find yourself starting him during your real quarterback’s bye.

WR Devery Henderson, Saints: Now that Marques Colston is out, the temptation will be to scoop up the leading receiver from Week 1's barnburner. But Henderson has a well-earned reputation as a fantasy tease.

WR Ted Ginn, 49ers: If you believe Ginn will continue his return-game heroics, then grab the 49ers’ defense/special teams. Because he’s worthless as a receiver.

Cam Newton